Conversion-of-5-FU-to-fluorodeoxyuridylic-acid-FdUMP-communications-homework-help
39.1 A patient with colonic cancer is being treated with 5-FU as well as leucovorin (N
5,N
10-methylene tetrahydrofolate). The rationale for administering the coenzyme depends on it being essential for:
5,N
10-methylene tetrahydrofolate). The rationale for administering the coenzyme depends on it being essential for:
A. Conversion of 5-FU to fluorodeoxyuridylic acid (FdUMP).
B. Protection against the anemia caused by 5-FU treatment.
C. The inhibition of thymidylate synthase by FdUMP.
D. Prolongation of the antitumor effect of 5-FU
39.2 Neutropenia develops in a patient undergoing cancer chemotherapy. Administration of which one of the following agents would accelerate recovery of neutrophil counts?
A. Leucovorin.
B. Filgrastim.
C. Prednisone.
D. Vitamin B
12.
12.
39.3 Hydration and/or diuresis can prevent the renal toxicity associated with:
A. Cisplatin.
B. Chlorambucil.
C. Tamoxifen.
D. Gemcitabine.
E. MTX.
39.4 A patient is being treated with allopurinol to control hyperuricemia resulting from chemotherapy. Which of the following would have to have its dose reduced to prevent toxicity?
A. 5-FU.
B. 6-MP.
C. 6-TG.
D. Fludarabine.
E. Cytarabine.
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